Angiopoietin-1 enhances skeletal muscle regeneration in mice
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منابع مشابه
TRANSLATIONAL PHYSIOLOGY Angiopoietin-1 enhances skeletal muscle regeneration in mice
Mahroo Mofarrahi, Joseph M. McClung, Christopher D. Kontos, Elaine C. Davis, Bassman Tappuni, Nicolay Moroz, Amy E. Pickett, Laurent Huck, Sharon Harel, Gawiyou Danialou,* and Sabah N. A. Hussain* Meakins-Christie Laboratories, Department of Medicine, McGill University, Montréal, Quebec, Canada; Department of Critical Care, McGill University Health Centre, Royal Victoria Hospital, Montréal, Que...
متن کاملAngiopoietin-1 enhances skeletal muscle regeneration in mice.
Activation of muscle progenitor cell myogenesis and endothelial cell angiogenesis is critical for the recovery of skeletal muscle from injury. Angiopoietin-1 (Ang-1), a ligand of Tie-2 receptors, enhances angiogenesis and skeletal muscle satellite cell survival; however, its role in skeletal muscle regeneration after injury is unknown. We assessed the effects of Ang-1 on fiber regeneration, myo...
متن کاملCOMP-angiopoietin-1 enhances skeletal muscle blood flow and insulin sensitivity in mice.
To test whether chronic enhanced blood flow alters insulin-stimulated glucose uptake, we measured skeletal muscle glucose uptake in chow-fed and high-fat-fed mice injected with adenovirus containing modified angiopoietin-1, COMP-Ang1, via euglycemic-hyperinsulinemic clamp. Blood flow rates and platelet endothelial cell adhesion molecule-1 positive endothelial cells in the hindlimb skeletal musc...
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OBJECTIVE Type 1 diabetes leads to impairments in growth, function, and regenerative capacity of skeletal muscle; however, the underlying mechanisms have not been clearly defined. RESEARCH DESIGN AND METHODS With the use of Ins2(WT/C96Y) mice (model of adolescent-onset type 1 diabetes), muscle regeneration was characterized in terms of muscle mass, myofiber size (cross-sectional area), and pr...
متن کاملSkeletal muscle degeneration and regeneration in mice and flies.
Many aspects of skeletal muscle biology are remarkably similar between mammals and tiny insects, and experimental models of mice and flies (Drosophila) provide powerful tools to understand factors controlling the growth, maintenance, degeneration (atrophy and necrosis), and regeneration of normal and diseased muscles, with potential applications to the human condition. This review compares the ...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
سال: 2015
ISSN: 0363-6119,1522-1490
DOI: 10.1152/ajpregu.00267.2014